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apalutamide will reduce the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medications which have been CYP3A4 substrates can result in decreased publicity to these remedies.As usually, nevertheless, usually u